Report from the Extreme Human Performance Center:

5 Days of Deadlifts In a Row

It ended in a PR (personal record) on the trap bar deadlift

Would you ever find a program that told you to deadlift 5 days in a row?

If you would, would you set a PR on it?

Granted this was different deadlift versions and different sets and reps, but all done via biofeedback as below

Exercise Program Design by Biofeedback Part 1-7

I have a ways to go for my deadlif goals, but setting a PR is always a step in the right direction.  There is nothing that special about me and this was done later at night than usual, after 5 days of lifting and higher stress than usual (planning a wedding, PhD dissertation writing, teaching, training others, work, etc).

Everyone is busy and biofeedback lets you adjust to YOUR stress EVERY time.

The Future Is Here.  Biofeedback training will be explained in full detail in the Gym Movements DVD very soon!

Here is a great tune from Earth Crisis to get you in the mood to go lift some heavy stuff.

Comments!

Let me know hear ‘em!

Rock on
Mike T Nelson

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Damien Walters Show Reel Video- How Do you Want To Move?

Damien Walter is a freak. You must watch this!

How Does He Train?

See this exclusive interview below

Damien Walters Interview

How Do You Want To Move?

Is Your Training Getting You Closer To Better Movement?

If Not, Why Not?

The Answer Is Coming Soon. The Movement Will Be Here……

rock on
Mike T Nelson

PS

Damien Walters I am not, but I will be working on the back flip again later in 2010 (must…..graduate……first)

Hardcore Parkour

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TRX Suspension Trainer Review

by the Professor via video from His lab

The professor is back again in his lab conducting more experiments on unsuspecting athletes. Today we are playing around with TRX Suspension Trainer to do some new exercises.

The first question is

Is This Easy To Set Up?

The short answer is YES, as shown in the video above. It only takes a couple minutes (at most) to have it set up. No more excuses about getting to the gym, bring the gym to you in minutes!

Never Miss A Workout Again!

The TRX Gym in a Bag weighs in only at 2 lbs and can fit in your suitcase, even with all the crazy new airline restrictions.

I personally find it that is is awesome when you travel since you can hook it up to pull up bars, trees, overhangs, and they even have an option that lets you use it from a door!

Excuses, Take a Hike!

No more excuses to not exercise when you travel now!  I love kettlbells, but they are a bugger to travel with and the TRX suspension trainer works great to do some unique exercises that you can’t do with just your bodyweight.

You can set it up almost anywhere!

It is also a great option for military personal that many times are left with less than stellar locations to get in a good training session or much equipment at times.

What’s In the Bag?

TRX Force Kit

From the Fitness Anywhere website about the TRX Force Kit:

Get into Peak Operational Readiness- or, in civilian terms, the best shape of your life. You’ll take your strength and endurance up to the level of America’s highest echelon of fighting forces when you follow TRX® creator and former Navy SEAL Randy Hetrick and Fitness Anywhere Director of Education Fraser Quelch through this one-two punch of a workout. Designed to be performed on alternating days, the two programs begin at a moderate level and ratchet up the training aggressively over a 12-week period, The DVD includes a bonus warm-up routine, two-real time workouts, exclusive tips and techniques from Hetrick and Quelch, and a handy workout log to track your personal progress.

Who Can Use It?

Just about any body can use it since the straps adjust and let you custom the effective weight to your strength levels.  There are many professional athletes from NFL quarterbacks to extreme sport athletes to soccer players such as:

• Drew Brees, NFL Quarterback, New Orleans Saints
• Heather Mitts, Pro Soccer Player, Two-time USA Olympic Gold Medalist
• Carmelo Anthony, Pro Basketball Player, Denver Nuggets
• Ronnie Faisst, Freestyle Motocross (FMX)) Rider
• Jeremy “Twitch” Stenberg, Freestyle Motocross (FMX)) Rider
• Holly Beck, Professional surfer and Surf Stronger athlete

Summary

If you are looking for something to have in your home gym or start your own home gym and take it on the road with you, this is great and I would recommend it.   If you have access to a full gym all the time it may not be for you, but even just taking one day  “off” from the normal gym and doing some bodyweight and TRX exercises at home will save you some time.

Stay tuned for more TRX exercises coming soon!

Any and all comments, let me know below!  I want to hear what YOU think!

Rock on

Mike T Nelson

Click HERE To Buy a TRX Portable Gym in a Bag today!

Exercise Program Design by Biofeedback Parts 1-7

Give Traditional Program Design the Finger and Destroy Your Old PRs!

So I was probably not supposed to deadlift tonight, but I like deadlifts and I wanted to try some B-Stance Deadlifts and Kettlebell Get Ups (formerly known as the Turkish Get Up, but I guess the Turks are not the only ones doing them).

I did a 2.5 hours bench-a-thon on Tuesday night with Dave “The Athlete Creator” and I hit an all time PR (personal record) on the bench at 240 lbs.  Not my end goal by any means, but moving forward and hitting all time PRs is great. To be fair we also did some neutral ring rows and kettlebell presses and kettlebell swings too. I was starting to have flashbacks for awhile there to pretty much any commercial gym on a Monday, which as you know is national bench and bicep curl day.

Squats and More Fun!

Wed night I hit up a lighter session of bottom pause squats (to an 8 inch box) for about 4 doubles, wide grip rope pull ups for singles and feet up push ups, which all tested well via biofeedback (as featured on the upcoming Gym Movements DVD).

I had not done any trap bar work in about 2 weeks so I hit up a nasty routine I’ve been working on. In short it is 10 x 10 but work to decrease the time. So Wed night I hit 265 x 10 for 10 in 21 minutes and 30 seconds for a total volume of 26,500 lbs. If you want the full details, leave a comment below and more than 12 comments and I will have a whole post with all the details.

More Deadlifts!

I did not sleep very well last night, had to work during the day, and decided to hit up some B-Stance deadlifts tonight as mentioned.

While the temp is never warm in the winter at the Extreme Human Performance Center (tonight it was 34 F, but the windchill was zero), the music on the stereo system is always amazing. Tonight was no exception and was provided by those Swedish death-medlers Soilwork.

Here is a great song by them (watch out, there are few bad words so if you are offended put on some ear muffs)

B-Stance deadlifts tested fine for awhile and worked up to 315 x 3 for 2 sets and the switched to regular deadlifts for a few singles (pronated, both palms down, for grip work) at 315.

Movement tested well, so I added 70 lbs of chains, went great! Whoo ha.  No problem at lockout either with all the chains off the floor.

Talking Weights

I had to head off to work, so I figured I would end on that high note and as I was cleaning up I saw a 25 lb plate that was just begging to be added to the bar (am I the only nut that thinks the weights talk to them?) I threw those on the end and after a long session on Tuesday, 2 sessions yesterday with a deadlift movement of 26,500 lbs and sore hams and glutes, 365 for a single was easy.  Very easy actually.

Summary

In the past I would have not even thought of doing deadlifts again and heck I probably would have opted to skip that day due to DOMS (muscle soreness). Now I have a tool to check it and test would is best.

Quality movement + volume = bigger muscles

If you are recovered, your body HAS to respond by increased strength and muscle hypertrophy (bigger muscles).

If you missed many of the biofeedback videos, I have posted them below here. This is a series that Adam T Glass did, so a huge shout out to Adam.

I feel so good I will probably hit up some kettlebells snatches yet tonight.    Whooo hahahahhaha.

Rock on
Mike T Nelson

PS

If you are interested in the routine from hell details of GVT meets EDT, leave a comment below and if I get 12 comments by this Sat night I will post it for you!  Spread the word.  You can help by signing up to my RSS feeds below and hit the button —>

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Biofeedback Videos

Intermittent Fasting and Eat Stop Eat Creator Brad Pilon Talks Sports Nutrition Supplements

Brad Pilon “Before and After”

I hinted in the past that I would have an insider come and tell us point blank what goes on the supplement industry and here we go!

What you will learn

• Do we need tons of supplements?
• Are there any that work?
• If you are using an Intermittent Fasting approach (like Eat Stop Eat), do you need supplements?
• Can I poke him to go off on a rant?

Let’s get right to it as we have Brad Pilon of Eat Stop Eat here today at Extreme Human Performance, so take it away Brad.

1) Give us a bit of background as you worked in the supplement industry.

Brad Pilon: I started in 2000 as a research analyst and by 2006 I was managing Clinical Research & Development. To be honest, it was probably in those 6 years that I learned the most about health, fitness, physiology and nutrition. We had access to so many unique sources of information. One day I would be talking anabolic signally pathways with leading researchers, the next day I’m talking protein with Mr. Olympia. It allowed for a wide scope of experience. Also, because our research was spread throughout the world, I was also able to view health and nutrition with a more worldly view, realizing that facts we assume to be true in North America are not nearly as widely accepted in academic circles in Germany or China.

I wouldn’t say it was a bad break up when I left, but more of a strained relationship. Looking back at it, I have nothing but respect for what the supplement industry has accomplished as an industry. Sure, I don’t agree with a lot of their claims or marketing tactics, but if you study it as an industry you realize that the “winning formula” hasn’t really changed since the late 1800’s. It’s the EXACT same marketing, the exact same sales pitch. It has worked for hundreds of years and it will continue to work for 100 more. So you really can’t expect it to change much.

2) Perhaps we can use the “winning formula” powers for good.   I heard a rumor from our buddy Craig Ballantyne that you are now the cover boy for some new supplements. What gives?

Brad Pilon: Ugh. Yeah. A while back I did a blog post showing how you can ‘fake’ before and after pictures. Basically I was trying to help people avoid being duped by BnA’s (editor’s note, that is industry geek speak for Before and Afters), by showing how much of a difference a tan, a shave, a pump and some oil can make in a picture. I guess I faked the picture a little to well because it was stolen by the Acai berry people and now is being used on fake websites all over the net. I get about 3 or 4 emails EVERYDAY form people finding my pictures (which sadly means that at least 3 or 4 people are reading Acai berry ads every day). When you think about it, it is VERY ironic. After all – They are using pictures that were openly faked to promote their products. Tells you something about these people’s integrity. I’ve contacted them, but they won’t stop using the pics. As annoying as it is, it is a bit flattering that they thought my pics were worth stealing.

3) Wow, that is crazy!  I am a very white Minnesota guy, so I am going to get a tan right now! ha!    Are their any supplements that you use or recommend?

Brad Pilon: I don’t really use any. I would recommend vitamin D for children living in Northern climates, and possibly EPA and DHA for children, but other than that I don’t often recommend supplements. I like creatine, and think it has an decent effect of increasing lean mass weight in first-time users, but even with creatine, after continued use the results simply aren’t there. Bottom line for me is that from a Dollar Cost versus Effect point of view, I’ve never found anything worth taking on a consistent basis for people who are otherwise healthy.

4) I would agree that fish oils and Vit D are both great.  Are their sports nutrition supplements that can or should be used with the Eat Stop Eat approach or are they not needed at all?

Brad Pilon:: When I first started experimenting with fasting I tried taking Glutamine, Branched Chain Amino Acids, Essential Amino Acids, 10 grams of Leucine, Leucine + Phenylalanine, anything I could get my hands on. I took these all while ‘fasting’. I took them in divided doses, all in one big dose, any way I could possibly think of. In the end, I have no idea why I bothered. I knew I wasn’t losing muscle, I wasn’t losing strength, and none of these things made any difference when I wasn’t fasting, so I have no idea why I thought they would when I was fasting. In the end, I think it was just a process of me letting go of a lot of my old bodybuilding beliefs.

5) Yes, the “broscience force” out there is still strong.  Any last parting words or rants?

Brad Pilon: There is lots to rant about, but that’s never really been my style, so I think I’d like to ’sound off’ on a little bit of on-line etiquette. Now, before I start, let me say that I am well aware that I am JUST as guilty of this as anyone else. So here is my rant – the use of scare quotes or irony quotes. You know, like referring to people as ‘experts’ or ‘gurus’, implying that these people are the farthest thing from actually being an expert or a guru.

People are doing this all the time now, using it as a form of passive aggressive mud-slinging. And, even though I’m opposed to much of what goes on in the on-line world of health and fitness, I think a lot of this mud-slinging is unneeded.

For instance, to me using ‘expert’ would be an appropriate way to define someone with an mail-order PhD trying to pass themselves off as the next nobel prize winner in health and fitness. Similarly, I think a ‘guru’ is someone who has ‘discovered’ a unique training style that only she and her disciples can fully understand. I once saw a blog post from a trainer saying that they know that research scientists say you can’t grow past your genetic potential, but that this trainer and found a way to cheat your genetics. Then said that maybe research scientists should spend more time in the gym and less time reading fancy books. To me, this would be a ‘guru’.

But for everyone else I think the term “fitness personality” is more fitting and much more honest. Most people on-line of people with a love of health and fitness who are trying to make a name for themselves, which on it’s own is perfectly fine.

When an on-line personal trainer says that they recently heard that blueberries can help you burn fat, it would be unfair to then call them a misinformed nutrition ‘expert’, because quite frankly, most of the time these people never claim to be experts. And, if we are turning to personal trainers for scientific explanations of human metabolism, then the fault is ours not theirs. After all, education is specific. Ask me how fasting causes you to lose body fat and I can ramble for hours. Ask me how an alternator in a car works and my eyes will glaze over.

So bottom line, anyone who is talking about fitness or nutrition on line is a fitness personality, but not necessarily an ‘expert’ or a ‘guru’, so calling someone an ‘expert’ or ‘guru’ just because you disagree with something they said is typically just a form of on-line mudslinging that really doesn’t do anyone any favors (we’d all be much better off if we just clearly explained why we disagreed with their opinion).

As I said, I’m just as guilty as anyone, but moving forward, it’s not something I’m going to do anymore, and I encourage everyone else to only use these terms when truly justified.

Thanks Brad,  I would agree with the online mud-slinging as I try hard to stay away from it, but I do admit to going off on a rant on occasion.  I do try hard to make my rants based on evidence and not just yell “you suck” as that is not helpful and nobody learns a darn thing from that interaction.

Summary

Thanks again to Brad Pilon of Eat Stop Eat for stopping by and taking the time to answer some questions.

As I have stated before in the this post that I do like his approach for fat loss.  While it took me almost 2 years to come around, I think it is a valid option and worth checking out.   You can read more information about it and a full hour long interview here below at

Review of Eat Stop Eat : Intermittent Fasting to Lose Body Fat

You can pick it up below

Eat Stop Eat click HERE

Comments

I love comments as they make me feel all warm and fuzzy.   What do you think of this?  Agree?  Disagree?  Do you want to see more interviews?  Post a comment and let me know!
Rock on

Mike T Nelson

PS

You can get Eat Stop Eat by clicking HERE

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Ouch, My Hip Hurts and My Glute Does Not WorK

Testimonial from Dave S in Minneapolis, MN, rock climbing enthusiast

After a long hiatus off of running I recently started up again, primarily trail running. I’ve been told on two separate occasions (about a month ago and about fifteen years ago) that my right glute does not engage while I run.

I suspect it’s why my running has always felt a little awkward. Previously, I just stopped running since it wasn’t enjoyable.

This time I sought Mike’s help getting my muscles to work the way they’re supposed to.

After seeing me walk, Mike determined that neither of my glutes were engaging properly. It took about an hour but Mike got both glutes functioning again.

I left with some Z-Health drills to make sure they continue to work the way they’re supposed to.

I will see Mike again and I’m looking forward to enjoying running again.

Thanks Mike.

Dave S.  Minneapolis, Minnesota

Thanks Dave for stopping by to get those glutes (butt muscles) going again!

Yes you read that right, in one session we got his glutes going again so that he can actually enjoy exercise and running again. One of them had not been working for 15 YEARS! I know that seems hard to believe, but with the right information it is possible to get your body working better now than ever before, all with less pain.

What Did We Do?

We followed this Z-Health based approach as below

Z Health Method for Injuries and Athletic Performance

In Dave’s case we needed all three -  joint, eye movements, and vestibular (head movements) to get him on the right track again.

Will It Stay?

He will work on his drills for a few times a day and this works to upgrade the software in his brain to keep his glutes working and keep running fast and fun.

What are you waiting for?  Email me by clicking HERE today to get started on moving, feeling and performing better!  Click HERE

Rock on

Mike T Nelson   Z Health Master Trainer

PS

If you are still not sure, every session is 100% guaranteed.If you are not happy for any reason, the session is free.

No strings, no catches, as your satisfaction is my highest priority. Most issues can see HUGE improvements in only one session.

Email me today by Clicking HERE

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Brett Farve Case Study:  Pain Decreases Performance

I am so stoked about the Vikings game this Sun night!  It is going to be close but I predict Adrian Peterson will have a break out game and silence the crowd, thus allowing Brett to pass for some major yardage and a win.

Can you say………Superbowl!!!  (Fingers crossed)

Pain Decreases Performance

As you know, I tend to write about pain because it has a bad effect on performance.

This is especially true for accuracy.  If you are in pain, your ability to accurately perform on the playing field will be diminished.

Let’s look at our good buddy Brett Farve.

You see that the number of interception last year (and some other years) was very high.  It was well know that Brett had a pesky shoulder that was causing him pain.  In 2008-09 he threw 22 interception and this year, only 7 so far to the wrong guy.

This year (after getting the pesky said shoulder fixed), the interceptions dropped by a ton!   Hmmmm…….

The Perfect Case Study?

Of course this is not a perfect case study in any sense, but my guess is that pain in his arm dramatically affected his passing accuracy.

What do you think?

Who Will Win This Sunday?

Drop a comment on who you think will win the big game this Sunday night vs the Saints!  I say Vikings!

Rock on

Mike T Nelson

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All Aboard the Biofeedback Bus: A Radical Tour of New Personal Records, Inspiration and Knowledge

Biofeedback testing is going great and athletes are busting PRs (personal records) left and right. Today we are going on a tour.

Be on the lookout for 1) results 2) inspiration  3) knowledge all leading up to more muscle and strength. All aboard the biofeedback bus and keep your hands inside at all times!

You cannot help men permanently by doing for them what they could and should do for themselves. ~Abraham Lincoln

Inspiration

The first stop we have is to pay homage to Josh “the World’s Strongest Librarian”  for racking up PRs (personal records) like a crazy man on a mission from God.  It must be the hat and shoes.

Read it and weep weakness!

First Goal of 2010 Fell Today: 500 lb Deadlift

Charles in Charge

Next stop is the firehouse where Charles Bustos RKC is putting the smack down on some poor, unsuspecting athlete.  He has graciously allowed us to view it too!

A Student of Your Own Body

Along the way we visit Geoff Neupert as he chimes in with his thoughts and results from biofeedback testing below

Become a student of your own body blog post

Why are PRs important?

Now our journey takes us north.  Like way the heck north to that cold desolate land that tests man willingness to live (and will freeze the feet on your bulldogs) in North Dakota.   Don’t blink as you will miss that one fence post.  Make sure to take a picture.

We find strongman and grip gorrilla Adam T Glass who takes us to the PR school of ultimate performance for a great lesson.

Programming and PRs Why Its Important

What Do YOU Think?

I hope you enjoyed our journey today through the land of strength and more muscle via the biofeedback bus.

Let me know what you think and what are your results so far?   I love comments!!

Rock on

Mike T Nelson

PS

The Gym Movements DVDs will be available soon, so stayed tuned here!

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Metabolic Flexibility: You Need to Burn That Fat Off!

Large and In Charge Mouse

I hope all of you got to watch the Vikings win this past Sunday!  Whoo ha!!

Onward to today’s topic of Metabolic Flexibility.

What is that and why do I care?

Physiology is Messy

Physiology is complex and messy.  Most theories just don’t hold up since they are too simple.  Note, this does NOT mean that the actions you need to take have to be complex, but the theory to explain all the inter-workings gets complicated at times.

Metabolic Flexibility (Met Flex) is the term to describe the ability of the body to burn both fats AND carbs efficiently.

Enter the Diabetic Stage Left

The basic definition of a diabetic is someone who does not handle carbs (carbohydrates) very well.  Their glucose management has gone awry and is messed up.  Don’t get me started on why the popular recommendation is then for diabetics is truck loads of CARBS!  Ok, just a short rant since it is my blog and I read research studies for fun.

Now to be entirely fair, the American Diabetes Association (ADA) has cracked the door a bit to  low-carb diets for people with diabetes and pre-diabetes (and insulin resistant) but for weight control ONLY and it doesn’t recommend low-carb diets for blood glucose control, even though the new guidelines say,

“dietary carbohydrate is the major determinant of postprandial [after meal] glucose levels”.

If you are a diabetic or borderline diabetic, dumping a crap ton (technical term) into your system of the very thing that you have a hard time processing, is a bad idea.

Toxic Sugar

Keep in mind that HIGH level of glucose (sugar) in the blood is TOXIC.   Low levels are also bad, so the body has tons of controls to keep you at a happy medium (homeostasis for my fellow geeks).    The downside is that some of these short term controls (read, so you don’t die) come at a very high cost long term (read: destruction of other tissues).

Fat Metabolism: Torch the Muffin Top

In the USA, Even the Wild Animals Are Now Fat!

source: James Marvin Phelps (mandj98)

On the other end of the spectrum, although not as common, are people who can’t handle high amounts of dietary fats.  The machinery that processes fat has gone off the tracks and this too results in lots of collateral damage.

Summary So Far

So those are the bad circumstances

1) poor handling of carbs

or

2) poor handling of fats

For all practical purposes, the burning of protein as a fuel does not happen that much; despite all the fear mongering of bro-scientists everywhere in the bodybuilding circles.

Now, some poor bastards can have BOTH (fat and carb metabolism) gone awry and are an unfortunate metabolic wreck.

The Good Side

So if that is the bad side, people who are very metabolically INflexible to fats and carbs; there is a good side -  people are who very metabolically flexible to carbs and fats.  This is where you want to be.

You want the ability to handle fats AND carbs without any collateral damage and increase your health and performance.

How?

The most profound effector of this is ………EXERICSE!   Any surprise there?  A high levels of exercise, your body becomes very efficient at handling fats AND carbs (2).  There is accumulating evidence (1) that lower levels of body fat are also correlated to metabolic flexibility.    We used to think that fat cell sat around on their collective fat butts all day, but we now know they run a host of chemical messengers throughout the body.  Fat as it turns out is very metabolically active (think busy fat cells not lazy ones).

Metabolically Flexible Robots?  What?

KITT from Knight Rider: A Smart Robot

Now I don’t believe much of anything I read on Fox news, but there was a story about the military making new robots that can eat anything.  Sweet!  A metabolically flexible robot!  I always knew DARPA was ahead of us.

from Fox News (yeah I know, I am quoting fox news, eeek)

“Robotic Technology Inc.’s Energetically Autonomous Tactical Robot — that’s right, “EATR” — “can find, ingest, and extract energy from biomass in the environment (and other organically-based energy sources), as well as use conventional and alternative fuels (such as gasoline, heavy fuel, kerosene, diesel, propane, coal, cooking oil, and solar) when suitable,” reads the company’s Web site.”

You gotta love the name too EATR.  ha!  For those that want to see the whole presentation on EATR, I tracked it down and you can get it HERE.

Are the Robots Ahead of Us?

It is time to add some more exercise and get more metabolically flexible soon, before a robot comes looking to eat you for lunch.    This also has a great side effect of decreasing that spare tire and muffin top too.

Sprints anyone?  Catch me if you can you lazy robot!

Rock on

Mike T Nelson

PS

For those that are interested in this topic, hold on to your hats as I have a whole product coming out soon called “The Truth about Protein, Fats, and Carbs: Implications for Metabolic Flexibility”   I am also in the process of writing up some studies for peer review on metabolic flexibility (silly dissertation).

REFERENCES

1) MITOCHONDRIAL RESPIRATION IS INCREASED FOLLOWING
LIPID EXPOSURE IN CULTURED MYOTUBES FROM LEAN BUT
NOT OBESE DONORS

Appl. Physiol. Nutr. Metab. Vol. 34, 2009
Boyle KE, Zheng D, Anderson ET, Neufer PD, & Houmard JA. Dept.
of Exercise & Sport Science & The Metabolic Institute, East Carolina
University, Greenville, NC

The skeletal muscle of obese humans oxidizes less lipid compared to
leans and is unable to respond to a lipid challenge. We utilized satellite
cells derived from vastus lateralis tissue of 7 lean (BMI=22) and 8 obese
(BMI=38) human males to determine the mechanisms involved with
the inability to utilize lipid with obesity. On day 6 of differentiation,
myotubes were incubated in differentiation media supplemented with
either 100?M oleate/palmitate + 0.05% BSA or 0.05% BSA for 24h. Cells
were then permeabilized and state 4, state 3, and uncoupled respiration
was measured in the presence of palmitoyl carnitine + malate (+succinate
for uncoupled). State 3 and uncoupled respiration increased in leans with
the lipid incubation (50% & 35%, respectively; P<0.05). There was no
corresponding change in the cells from obese donors. Mitochondrial
DNA copy number increased in leans but decreased in obese with lipid
incubation (16% & -13%, respectively; P<0.05) and COX-IV protein
content showed a significant lipid incubation x body size interaction (38%
increase in leans and -13% decrease in obese; P<0.05). These data suggest
that the skeletal muscle of obese individuals does not respond to lipid
exposure by increasing lipid oxidation; this metabolic inflexibility may be
a mechanism involved in the reduced ability to oxidize lipid evident in the
muscle of obese subjects.
Funded by NIH DK561112 & DK073488.

2) ADAPTATIONS IN NR4A3 ISOFORMS FOLLOWING EXERCISE
TRAINING IN OBESE HUMANS
Appl. Physiol. Nutr. Metab. Vol. 34, 2009

Haus, J.M., Solomon, T.P., Kirwan, J.P. Cleveland Clinic, Cleveland, OH

The orphan nuclear receptor NR4A3 responds to acute exercise and
has been implicated in the regulation of genes that mediate glucose
and lipid metabolism in skeletal muscle. Data on the effects of exercise
training on NR4A3 gene expression are lacking. We examined mRNA
expression of the known NR4A3 isoforms (A,B,C) from muscle biopsy
samples obtained at basal and under insulin stimulated conditions (INS)
during a 40 uU/m2/min hyperinsulinemic-euglycemic clamp before and
after 12 weeks of aerobic exercise training. Subjects included obese
men and women. At baseline, NR4A3 isoform C was most abundant
(2.7±1.1, 3.5±1.4, 5.6±1.7 AU), and INS increased expression of all three
isoforms (3.4, 1.6, 4.7 fold; P<0.05). Exercise training increased basal fat
oxidation, glucose disposal rates (GDR) and basal mRNA expression of
NR4A3 isoforms B and C (1.4 and 2.1 fold; P<0.05 vs. pre). In addition,
the expression of NR4A3 isoforms A, B and C were decreased during INS
(-55, -29, -61% vs. Pre INS). Following exercise training, increased basal
expression of NR4A3 isoforms B and C may reflect the increase in basal
whole body fat oxidation. The exercise-induced attenuation of NR4A3
gene expression during INS is consistent with the observed improvements
in metabolic flexibility following exercise training. These novel data
provide evidence that NR4A3 may regulate glucose and lipid metabolism
following exercise training in obese, insulin resistant adults

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The other day I had a contest giving away my upcoming “Truth about protein, fats and carbohydrates” lecture for just placing a comment regarding my review of Eat Stop Eat and interview with Brad Pilon.

If you missed it, check it out here

Review of Eat Stop Eat: Intermittent Fasting to Lose Body Fat

The Winner Is……

And the winner is (drum roll)……………. Mat L.

So Matt, check your email and I will have it out to you later today.

Thanks for all that participated in the contest, much appreciated!

I am off to watch the Vikings beat up the Cowboys in just a few minutes with Jodie

Rock on

Mike T Nelson